Corporate Advisory Board
The CNF PERF Scientific Research Grant is a two-year grant for work in the field of child neurology. This award recognizes the work of a young researcher, who is a child neurologist early in his/her career. The selected investigator will receive a $100,000 grant of $50,000 per year for two years.
The award is supported fully by the Pediatric Epilepsy Research Foundation (PERF).
Washington University in St. Louis, School of Medicine, Neurology and Pediatrics
“Brain Oxygen Metabolism in Sickle Cell Disease”
This award from the Child Neurology Foundation will give a critical foundation to my research career. With this generous funding, I can complete the groundwork for a larger multicenter trial to reduce strokes in children.The Child Neurology Foundation Scientific Research Award will allow me to investigate the underlying mechanisms of stroke in children. I will use non-invasive MRI techniques tomeasure cerebral blood flow and oxygen metabolism in children with sickle cell disease, one of the highest risk populations for childhood stroke. Right now, we know that transfusions can help prevent strokes in some children. However, because we cannot tell which children would gain the most benefit, almost all children are started on lifelong monthly transfusions, which are a tremendous burden to the patients, their families, and society. I hope to use MRI to improve stroke risk assessment in children with sickle cell disease so that we can decrease the transfusion burden in some children and be aggressive in preventing stroke in others. Ultimately, I hope this research will contribute to the worldwide effort to stop stroke in children.
Division of Pediatric Neurology
Washington University School of Medicine
Receiving the 2013 CNF PERF Scientific Research Award represents a great honor. More importantly, it creates the opportunity to initiate a research program aimed at understanding how intensive therapies affect the brains’ of children with brain injury. Greater knowledge of the brain changes caused by practice-based therapies is critical for improving their efficacy. In addition, mapping the relationships between therapies, brain changes and functional outcomes may open up new therapeutic approaches towards enhancing brain recovery. Thus, the 2013 CNF PERF Scientific Research Award will fund MRI brain imaging studies of children with chronic brain injury and one-sided movement deficits undergoing an intensive therapy regimen called constraint-induced movement therapy (CIMT). Advanced functional MRI techniques will be utilized to carefully trace changes in brain function and brain connectivity attributable to the intervention. These changes will then be related to detailed quantifications of motor function. We contend that this approach will advance our understanding of use-dependent neuroplasticity in general and create testable hypotheses about how current treatments could be further improved.
Child Neurology Foundation
201 Chicago Avenue #200
Minneapolis, MN 55415