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Dysautonomia

Description

Dysautonomia refers to a disorder of autonomic nervous system (ANS) function that generally involves failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive or overactive ANS actions also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

Treatment

There is usually no cure for dysautonomia. Secondary forms may improve with treatment of the underlying disease. In many cases treatment of primary dysautonomia is symptomatic and supportive. Measures to combat orthostatic hypotension include elevation of the head of the bed, water bolus (rapid infusion of water given intravenously), a high-salt diet, and drugs such as fludrocortisone and midodrine.

Prognosis

The outlook for individuals with dysautonomia depends on the particular diagnostic category. People with chronic, progressive, generalized dysautonomia in the setting of central nervous system degeneration have a generally poor long-term prognosis. Death can occur from pneumonia, acute respiratory failure, or sudden cardiopulmonary arrest.

Research

The NINDS supports and conducts research on dysautonomia. This research aims to discover ways to diagnose, treat, and, ultimately, prevent these disorders. Information from the National Library of Medicine’s MedlinePlusAutonomic Nervous System Disorders

Dysautonomia Foundation

Address:
315 W. 39th Street
Suite 701
New York, NY 10018

Website: http://www.familialdysautonomia.org
Phone: 212-279-1066
Fax: 212-279-2066

Non-profit organization that supports medical research grants and clinical care; provides information; and offers chapters nationwide and overseas.

Dysautonomia International

Address:
P.O. Box 596
East Moriches, NY 11940

Organization  founded in 2012 by patients, caregivers, physicians and researchers dedicated to assisting people living with various forms of dysautonomia and increasing awareness of different medical conditions that cause a malfunction of a person's autonomic nervous system . More importantly, Dysautonomia International is dedicated to finding a cure and better treatments for each form of dysautonomia.

Dysautonomia Youth Network of America, Inc.

Address:
1301 Greengate Court
Waldorf, MD 20601

Website: http://www.dynainc.org
Phone: 301-705-6995
Fax: 301-638-DYNA

Nonprofit support and outreach network dedicated to serving youth diagnosed with various dysautonomia conditions. Provides peer and educational support, serves as a member forum for parents and youth, and sponsors a summer conference.

Familial Dysautonomia Hope Foundation, Inc. (FD Hope)

Address:
121 South Estes Drive
Suite 205-D
Chapel Hill, NC 27514-2868

Website: http://www.fdhope.org
Phone: 919-969-1414

Non-profit organization that works to expand and accelerate research towards a cure for familial dysautonomia and to improve the lives of children and adults challenged by the disease. Funds research programs, provides a support network for patients and families, and promotes education and awareness in the medical community and public.

National Dysautonomia Research Foundation

Address:
P.O. Box 301
Red Wing, MN 55066-0301

Website: http://www.ndrf.org
Phone: 651-327-0367
Fax: 651-267-0524

Non-profit foundation established to help those afflicted with any of the various forms of dysautonomia. Provides a support network for affected individuals and family members by providing information on the various forms of dysautonomia, as well as providing contacts to other organizations that may be of assistance.

The Multiple System Atrophy Coalition

Address:
9935-D Rea Road
Charlotte, NC 28227

Website: http://www.multiple-system-atrophy.org
Phone: 866-737-5999

National support group that collects and disseminates information and promotes education and support for people affected by Shy-Drager Syndrome or multiple system atrophy.



Information sourced through CNF’s partnership with The National Institute of Neurological Disorders and Stroke (NINDS), US National Institutes of Health.